Adrenal cortex function9/15/2023 ![]() This enabled us to detect hormones at a lower level than in the past. We also have access to liquid chromatography mass spectrometry, which is a very sensitive method for detecting steroids. We have access to some of the world’s largest Addison’s disease registries in Norway and Sweden, which we used to recruit 192 patients. How do you explore adrenal cortical function? We wanted to investigate the varied adrenal cortex function in Addison’s disease patients systematically. ![]() There have even been examples of partial restoration of adrenal cortical function. In the last decade, some case reports suggested that some patients preserve adrenal cortical function for years after their initial diagnosis. ![]() However, I have never seen a study directly supporting that statistic. There is a statistic commonly referenced in the literature that patients develop symptoms and signs of Addison's disease once they lose more than 90% of their adrenal cortical tissue. What led you to do a clinical trial to test if patients could still produce corticosteroids? ![]()
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